Identifying Strategies to Reduce Poor Outcomes in Women With Stroke
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Despite advances in care, stroke remains a leading cause of mortality and long-term disability around the world for both women and men.1 There are, however, notable sex differences in the epidemiology of stroke, including differences in incidence and mortality. Across the lifespan, women have a greater lifetime risk of stroke, a greater risk of death from stroke, and a higher risk of poor functional outcomes after stroke than men.2,3 A better understanding of the contributors to sex differences in stroke mortality could lead to the identification of strategies to improve stroke outcomes in women, as well as men. A study published in this issue by Phan et al4 included a meta-analysis using individual participant data from population-based studies to examine the contributors to sex differences in long-term mortality after stroke. The authors’ process of identifying contributors to the sex–mortality association in individual studies before combining data in a meta-analysis allowed them to clarify which factors contribute to higher stroke mortality in women and to identify potentially modifiable factors leading to poor stroke outcomes.
See Article by Phan et al
Their study is a meta-analysis of 13 studies of stroke incidence based on ideal population-based data sets; individual stroke incidence studies were conducted across Europe, Australia, South America, and the Caribbean between 1987 and 2013. Study authors examined all-cause mortality at 1 year after incident stroke in 13 studies (almost 17 000 patients) and all-cause mortality at 5 years after stroke in 8 studies (over 13 000 participants). Mortality rates were compared in …