Abstract 183: Optimal Medical Therapy for Cardiovascular Disease in the Obese Undergoing Elective Percutaneous Coronary Intervention: Insights from the VA CART Program
Background: Stigma against obese patients is well described in primary care settings and may contribute to bias in therapeutic decision-making. It is unknown if similar stigma exists in obese patients referred for elective PCI. Accordingly, we evaluated the association between body mass index (BMI) and pre-procedural guideline-recommended medication use in patients undergoing elective PCI. The presence of lower medication use in overweight and obese patients may suggest the presence of a treatment bias.
Methods: Using data from the VA Clinical Assessment, Reporting, and Tracking System (CART) Program, we identified patients undergoing elective PCI from 2007-2012. We classified patients by BMI into normal (19-25), overweight (25-30), obese (>30). Rates of guideline-indicated medication use by BMI were assessed among eligible patients: beta-blockers (BB) for HF or prior MI, statins for CAD or equivalent (DM, CVD, PAD), anticoagulation for AFib and CHADS2> 1, and ACEI/ARB for HF. We also assessed composite rates of BB and statin in eligible MI patients and BB and ACEI/ARB use in eligible HF patients, respectively. Multivariable logistic regression analyses assessed the association between BMI class and use of indicated medications.
Results: Among 9,630 patients undergoing elective PCI from 2007-2012, 13.9% of patients had normal BMI, 35.6% overweight, and 50.6% obese. Overweight and obese patients were more likely to have sleep apnea, HTN and DM, while normal BMI patients were more likely to smoke, have lung disease, and CVD. Rates of medication use ranged from 45% to 69% depending on the class of medication assessed. After adjustment for CV risk factors, overweight and obese patients were more likely to receive statins and ACE/ARBs and equally likely to receive the other classes of medications compared to normal BMI patients (Table).
Conclusions: Over 85% of patients undergoing elective PCI in the VA are overweight or obese. Rates of indicated medication use remained low across BMI categories (<70%). There was an association between overweight and obese patients with greater use of some guideline-indicated medications, suggesting that a treatment bias against obesity prior to elective PCI does not exist. Future studies should assess for any impact of BMI on treatment of patients during and following elective PCI.
Author Disclosures: J.A. Valle: None. C.I. O'Donnell: None. A.J. Klein: None. E.J. Armstrong: None. T.M. Maddox: None. P.M. Ho: None.
- © 2014 by American Heart Association, Inc.