Abstract 360: Hypovitaminosis D and the Risk of Obstructive Sleep Apnea
Background: The prevalence of hypovitaminosis D has greatly increased in the American population, and is now estimated at 45%. There is increasing evidence that vitamin D is not only important for bone health but vitamin D deficiency is linked to chronic disease such as cardiovascular disease (CVD), diabetes, and cancers. The American obesity epidemic has increased the prevalence of Obstructive Sleep Apnea (OSA) in the American population. Patients with OSA are not just at risk for increased fatigue and daytime drowsiness but when untreated, OSA can increase the risk for a broad range of cardiovascular morbidities, such as hypertension, coronary artery, disease, and heart failure. Since vitamin D deficiency and OSA have independently been associated with CVD it is crucial to assess their relationship to each other. Few studies to date have examined the relationship between low levels of serum 25 hydroxyvitamin D (Vit-D) and risk for OSA. We aim to show a relationship between hypovitaminosis D and OSA in a large population.
Methodology: We evaluated 813 participants in the World Trade Center-CHEST Program from January 2011 to September 2013. After excluding those taking vitamin D supplementation, analysis was performed on 624. Blood samples were analyzed for various laboratory parameters including Vit-D and hs-CRP. Vit-D insufficiency was defined as Vit-D < 30 ng/ml. Using the Berlin Questionnaire, a validated questionnaire to evaluate OSA risk, subjects were classified as low risk or high risk. In addition, those with self-reported physician diagnosis of OSA were classified separately. Independent t-test, ANOVA, and chi-squared analyses were performed.
Results: Insufficient Vit D was noted in 74.5% (468) of the participants. Subjects who screened positive for high risk of having OSA had lower mean Vit-D levels compared with those with low risk for OSA. Those with the lowest mean Vit-D level were most likely to have a verified diagnosis fsleep apnea (p=0.015).
Conclusion: A significant association was found between hypovitaminosis D and OSA in this study population. Those with high risk for OSA and diagnosed OSA have significantly decreased Vit D levels. It is imperative to evaluate Vitamin D levels and OSA risk in order to achieve optimal management of CVD.
Author Disclosures: J. Janneck: None. R.L. Iyengar: None. C. Maceda: None. H.N. Beebe: None. Y. Yakunina: None. S.T. Sawit: None. L. Crowley: None. M. Woodward: None. M. McLaughlin: None.
- © 2014 by American Heart Association, Inc.