End Point | EDTA Chelation (n=322) | Placebo (n=311) | Hazard Ratio (95% CI) | P Value | Adjusted^{*} | |
---|---|---|---|---|---|---|
CI | P Value | |||||
Primary end point | 80 (25%) | 117 (38%) | 0.59 (0.44–0.79) | <0.001 | 0.39–0.88 | 0.002 |
Death | 32 (10%) | 50 (16%) | 0.57 (0.36–0.88) | 0.011 | 0.30–1.06 | 0.099 |
MI | 16 (5%) | 30 (10%) | 0.48 (0.26–0.88) | 0.015 | 0.20–1.13 | 0.135 |
Stroke | 4 (1%) | 3 (1%) | 1.19 (0.27–5.30) | 0.829 | 0.14–9.88 | … |
Coronary revascularization | 48 (15%) | 62 (20%) | 0.68 (0.48–0.99) | 0.042 | 0.40–1.16 | 0.378 |
Hospitalization for angina | 5 (2%) | 6 (2%) | 0.72 (0.22–2.36) | 0.588 | 0.13–3.87 | … |
Secondary end point | 35 (11%) | 52 (17%) | 0.60 (0.39–0.91) | 0.017 | 0.32–1.09 | 0.153 |
Cardiovascular death | 19 (6%) | 27 (9%) | 0.63 (0.35–1.13) | 0.118 | 0.27–1.44 | … |
CI indicates confidence interval; and MI, myocardial infarction.
↵* Bonferroni adjustment for 9 subgroup factors. CIs are adjusted to a level of 99.4%, and P value is 9× the nominal P value.