Table 2.

Baseline Characteristics of Patients With Diabetes by Infusion Arm

EDTA Chelation (N=322)Placebo (N=311)P Value
Demographics
 Age, y65.1 (60.3, 71.1)66.2 (58.8, 71.5)0.843
 Women55 (17%)64 (21%)0.260
 Minority (Hispanic or non-white)31 (10%)37 (12%)0.357
 BMI, kg/m231.1 (27.9, 35.9)32.1 (28.4, 36.4)0.208
History
 Time from qualifying MI to randomization, y*4.2 (1.6, 8.8)5.1 (1.4, 9.5)0.457
 Anterior MI128 (40%)111 (36%)0.292
 Congestive heart failure76 (24%)69 (22%)0.672
 Valvular heart disease34 11%)34 (11%)0.821
 Stroke26 (8%)25 (8%)0.987
 Peripheral vascular disease69 (22%)67 (22%)0.954
 Hypertension251 (78%)243 (78%)0.955
 Hypercholesterolemia273 (86%)255 (84%)0.436
 Atrial fibrillation36 (12%)49 (16%)0.086
 Former cigarette smoker181 (56%)173 (56%)0.882
Coronary revascularization
 CABG163 (51%)150 (48%)0.548
 PCI187 (58%)166 (53%)0.234
 Either CABG or PCI271 (84%)244 (78%)0.065
Presenting characteristics
 Blood pressure
  Systolic130 (120, 140)130 (120, 140)0.681
  Diastolic74 (68, 80)74 (68, 80)0.937
Concomitant medications
 Aspirin278 (86%)253 (81%)0.088
 β-blocker248 (77%)229 (74%)0.323
 Statin247 (77%)232 (75%)0.536
 ACEi or ARB234 (73%)226 (73%)1.000
 Clopidogrel86 (28%)75 (25%)0.550
 Warfarin34 (11%)31 (11%)0.845
 Aspirin, warfarin, or clopidogrel296 (93%)286 (92%)0.909
 Diabetes mellitus medication
  Insulin73 (23%)87 (29%)0.114
  Oral hypoglycemic191 (60%)189 (63%)0.585
 Multivitamin115 (37%)127 (43%)0.112
 Other vitamins/minerals142 (45%)150 (51%)0.147
 Herbal products94 (30%)96 (33%)0.419
Laboratory examinations
 Fasting glucose, mmol/L7.1 (5.9, 8.9)7.4 (6, 9.1)0.167
 Creatinine, μmol/L88.4 (79.6, 114.9)97.2 (79.6, 114.9)0.019
 Total cholesterol, mmol/L4.1 (3.5, 4.9)4.3 (3.6, 5.2)0.037
 HDL, mmol/L1.1 (0.9, 1.2)1.1 (0.9, 1.2)0.553
 LDL, mmol/L2.1 (1.6, 2.7)2.2 (1.6, 3)0.111
 Triglycerides, mmol/L1.7 (1.2, 2.5)1.8 (1.2, 2.7)0.299
  • ACEi indicates angiotensin-converting enzyme inhibitor; ARB, angiotensin receptor blocker; BMI, body mass index; CABG, coronary artery bypass graft; HDL, high-density lipoprotein; LDL, low-density lipoprotein; MI, myocardial infarction; and PCI, percutaneous coronary intervention.

  • * Median, 25th and 75th percentiles are reported for all continuous variables.