Table.

Baseline Characteristics of Patients in the Study Population (N=9361)

Major Adverse Cardiovascular Events or Death, n (%)Treatment-Related Serious Adverse Events, n (%)
Yes (n=755)No (n=8606)P ValueYes (n=338)No (n=9023)P Value
Assigned to intensive BP arm, n (%)332 (44.0)4346 (50.5)<0.001220 (65.1)4458 (49.4)<0.001
Age, mean±SD71.9±10.067.6±9.3<0.00171.5±9.667.8±9.4<0.001
Male sex, n (%)532 (70.5)5497 (63.9)<0.001211 (62.4)5818 (64.5)0.438
Black race201 (26.6)2746 (31.9)0.002108 (32.0)2839 (31.5)0.849
BMI, kg/m2, mean±SD29.3±5.829.9±5.80.00929.4±5.729.9±5.80.169
Systolic blood pressure, mm Hg, mean±SD141.3±16.4139.5±15.50.002141.1±16.2139.6±15.60.078
Diastolic blood pressure, mm Hg, mean±SD75.9±12.978.3±11.8<0.00176.0±12.278.2±11.9<0.001
Current smoker, n (%)132 (17.6)1108 (12.9)<0.00153 (15.7)1187 (13.2)0.185
Serum creatinine, mg/dL, mean±SD1.2±0.51.1±0.3<0.0011.2±0.41.1±0.3<0.001
eGFR MDRD, mL/min/1.73 m2, mean±SD65.7±22.872.3±20.3<0.00163.2±20.572.1±20.5<0.001
Urine albumin/creatinine ratio, mg/g Cr, median (IQR)17.0 (7.8–53.5)9.2 (5.5–19.8)<0.00113.7 (6.7–41.6)9.4 (5.6–21.0)<0.001
History of clinical CVD, n (%)244 (32.3)1318 (15.3)<0.00177 (22.8)1485 (16.5)0.002
History of subclinical CVD, n (%)55 (7.3)438 (5.1)0.00926 (7.7)467 (5.2)0.041
10-year CVD risk (Framingham equation), mean±SD24.9±13.219.7±10.5<0.00121.9±12.220.0±10.80.001
Total cholesterol, mg/dL, mean±SD185.6±43.0190.5±41.00.001187.0±43.5190.2±41.10.151
HDL cholesterol, mg/dL, mean±SD51.5±14.753.0±14.40.00655.5±16.052.8±14.4<0.001
Fasting triglycerides, mg/dL, mean±SD130.7±76.7125.5±91.60.131116.3±58.4126.3±91.50.046
Fasting plasma glucose, mg/dL, mean±SD99.2±13.598.8±13.60.39399.3±14.098.8±13.50.534
Statin use, n (%)379 (50.5)3675 (43.1)<0.001165 (49.4)3889 (43.4)0.031
Daily aspirin use, n (%)443 (58.8)4313 (50.3)<0.001204 (60.4)4552 (50.6)<0.001
Number of antihypertensive agents2.0±1.11.8±1.0<0.0012.2±1.01.8±1.0<0.001
  • Clinical CVD includes one or more of myocardial infarction, acute coronary syndrome, >50% coronary/carotid/peripheral artery stenosis or revascularization, or abdominal aortic aneurysm ≥5 mm. Subclinical CVD includes one or more of coronary artery calcium score ≥400, ankle–brachial index ≤0.90, or left ventricular hypertrophy. BMI indicates body mass index; CVD, cardiovascular disease; eGFR MDRD, estimated glomerular filtration rate calculated using Modification of Diet in Renal Disease study equation; and IQR, interquartile range.