Table.

Organs Damaged by Physiological Mechanisms Triggered by Heat Exposure

OrgansMechanisms
IschemiaHeat CytotoxicityInflammatory ResponseDisseminated Intravascular CoagulationRhabdomyolysis
BrainEmbedded ImageEmbedded ImageEmbedded ImageEmbedded Image
HeartEmbedded ImageEmbedded ImageEmbedded Image
IntestinesEmbedded ImageEmbedded ImageEmbedded ImageEmbedded Image
KidneysEmbedded ImageEmbedded ImageEmbedded ImageEmbedded ImageEmbedded Image
LiverEmbedded ImageEmbedded ImageEmbedded ImageEmbedded ImageEmbedded Image
LungsEmbedded ImageEmbedded ImageEmbedded ImageEmbedded Image
PancreasEmbedded ImageEmbedded Image
  • These interactions should be taken as feasible pathways through which heat can damage vital organs and result in death. The frequency in which these pathways were cited in the literature cannot be used as indication of the risk of occurrence of specific pathways because publications are more likely related to the extent to which novel insights are obtained for the different pathways as opposed to how frequent they occur. Supporting references are provided in Table I in the Data Supplement.